Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse
effects including neuronal cytotoxicity and tumor invasiveness and resistance to therapy.
Although it has been suggested that the physical microenvironment has a key role in tumor
angiogenesis and progression, the mechanism by which physical properties of extracellular
matrix control tumor angiogenesis and glioblastoma progression is not completely …